If a patient with PaO2 45 mm Hg on 60% inspired oxygen is titrated to reach PaO2 60 mm Hg, what FiO2 should be set?

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Multiple Choice

If a patient with PaO2 45 mm Hg on 60% inspired oxygen is titrated to reach PaO2 60 mm Hg, what FiO2 should be set?

Explanation:
Oxygenation rises roughly in proportion to the inspired oxygen fraction in a stable patient, so the PaO2/FiO2 ratio can guide adjustments. Here, PaO2 is 45 mmHg on FiO2 0.60, giving a PaO2/FiO2 ratio of 75. To reach a PaO2 of 60 mmHg while keeping that ratio, set FiO2 = 60 / 75 = 0.80 (80%). So the FiO2 should be increased to 0.80. In practice, monitor closely after such changes since lung perfusion and shunt can alter the response.

Oxygenation rises roughly in proportion to the inspired oxygen fraction in a stable patient, so the PaO2/FiO2 ratio can guide adjustments. Here, PaO2 is 45 mmHg on FiO2 0.60, giving a PaO2/FiO2 ratio of 75. To reach a PaO2 of 60 mmHg while keeping that ratio, set FiO2 = 60 / 75 = 0.80 (80%). So the FiO2 should be increased to 0.80. In practice, monitor closely after such changes since lung perfusion and shunt can alter the response.

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